Application of an almost traceless linker in the synthesis
[Show full abstract] reaction that involves the tethering of two phenyl groups by a temporary, traceless sulfonamide linker that directs a photochemical aryl fusion into a single coupling product Traceless Cleavage of Protein–Biotin Conjugates under Sep 05, 2017 (PDF) Traceless Photolabile Linker Expedites Chemical Here, we describe a traceless photolabile linker to prepare car-bohydrates with a free reducing end. Modification of the o-nitrobenzyl scaffold of the linker is key to high yields and Traceless Staudinger Ligation for Biotinylation of Title:Traceless Staudinger Ligation for Biotinylation of Acetylated Thiol-Azido Heterobifunctional Linker and Its Attachment to Gold Surface VOLUME: 22 ISSUE: 4 Author(s):Subhadip Senapati*, Sudipta Biswas and Peiming Zhang* Affiliation:Biodesign Institute and School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, Biodesign Institute and School of Molecular Sciences, Arizona
(PDF) Metal‐Free Aryl Cross‐Coupling Directed by Traceless
A traceless linker strategy for the solid-supported synthesis of 5-benzoylbenzimidazoles has been developed. A benzyl cyanide functional group was linked to 2% divinylbenzene cross-linked polystyrene through a dimethylsilyl linker. Linkers for Solid‐Phase Organic Synthesis (SPOS) and Traceless Linker Based on Sulfones. Traceless Concept Based on Cycloaddition‐Cycloreversion. Photolabile Linker Units Introduction. Linkers Based on o‐Nitrobenzyl Photocleavable Linker Based on Pivaloyl Glycol. Safety‐Catch Linkers. Dual Linkers and Analytical Constructs
A comparison of three linker types, (1) noncleavable, (2) cleavable but nontraceless, and (3) traceless, reveals up to an 8-fold improvement in T-cell proliferation when the traceless linker is used. This work underscores the critical importance of the choice of conjugation chemistry in vaccine development.
Solid-Supported Reagents in Organic Synthesis Poly-TPP as a traceless linker. An additional application of poly-TPP is the synthesis of (E)-nitro olefins by isomerization of (Z)-nitro olefins.21The nitro olefins are prepared as a mixture of E/Zisomers via a nitroaldol reac-tion followed by dehydration of the b-nitro alcohols. Treatment of this mixture with a … CiteSeerX — Acid-labile traceless click linker for protein CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): ABSTRACT: Intracellular delivery of active proteins presents an interesting approach in research and therapy. We created a protein transduction shuttle based on a new traceless click linker that combines the advantages of click reactions with implementation of reversible pH-sensitive bonds.